Join Zoom Meeting:
https://columbiacuimc.zoom.us/j/98062087107?pwd=ODN1TFwbtR23dO0Pk7Bq73td7fG91L.1
Meeting ID: 980 6208 7107
Passcode: 267022
Parisa Yousefpour, PhD (left)
Assistant Professor of Biomedical Engineering
Department of Biomedical Engineering
Program: Tumor Biology and Microenvironment (TBM)
Title: Engineering Self-amplifying RNA with Controlled Interferon Responses
Description: Self-amplifying RNA (saRNA) is an emerging RNA modality that enables sustained protein expression from low doses. However, due to its self-amplifying nature, saRNA can also trigger innate immune responses, including type I interferon responses, that can limit its activity. In this talk, I will discuss how interferon (IFN) signaling influences saRNA amplification and expression, and present strategies to regulate saRNA replication using small-molecule–responsive gene circuits. These approaches provide a way to tune RNA expression and immune activation for therapeutic applications, including cancer immunotherapy.
Aiwu Ruth He, MD, PhD
Professor of Medicine
Department of Medicine, Hematology & Oncology
Program: Precision Oncology and Systems Biology (POSB)
Title: Investigate predictive biomarkers of treatment response in hepatocellular carcinoma (HCC)
Description: This talk focuses on identifying and evaluating factors that can predict how patients with hepatocellular carcinoma (HCC) respond to different treatments.
