Jaewon Min, PhD, (left) Assistant Professor of Pathology and Cell Biology (in the Institute for Cancer Genetics); Member HICCC Cancer Genomics and Epigenomics Program
Telomerase-independent telomere maintenance mechanisms in human cancers
Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism that frequently occurs in mesenchymal origin human cancers. This talk will present our recent work to identify how cancer cells acquire telomere maintenance mechanisms independent of telomerase during tumorigenesis and how to target such telomere maintenance mechanisms as an anti-cancer strategy.
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Neil Vasan, MD, PhD, Assistant Professor of Medicine, Division of Hematology & Oncology; Member, HICCC Precision Oncology aFunctional analysis of PIK3CA variants in cancer nd Systems Biology Program
Functional analysis of PIK3CA variants in cancer
Precision oncology requires predicting how cancer gene variants function in each patient. PIK3CA is one of the most frequently mutated oncogenes in cancer with ~1000 distinct clinical variants, and PIK3CA mutations are a biomarker of response to PI3K inhibitors. This talk will present our efforts to functionally analyze PIK3CA variants and their effects on PI3K activity, cell growth, and sensitivity to PI3K inhibitors.
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Meeting ID: 999 0430 6839
Passcode: seminar
