Andrew J Ewald, PhD, Professor of Cell Biology, Johns Hopkins University School of Medicine
Cellular and Molecular Mechanisms of Breast Cancer Metastasis
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Meeting ID: 981 2799 7676
Passcode: 884782
The majority of cancer mortality is attributable to metastasis, the process by which cells escape from the primary tumor, access the systemic circulation, evade the immune system, and colonize distant organs. Our recent work demonstrated that metastasis can be accomplished by cancer cells that travel through the body in adherent clusters, while retaining and requiring epithelial gene expression. We are currently working to test the limits of our “collective epithelial metastasis” model in the context of triple negative breast cancer. This talk will present published and ongoing work aimed at understanding the regulation of breast cancer metastasis by both cancer cell-intrinsic and tumor microenvironment-mediated mechanisms.
